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PPAR gamma (PPARG) Human shRNA Plasmid Kit (Locus ID 5468)

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SKU
TR320459
PPARG - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 5468
Synonyms CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PPARG - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5468). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001330615, NM_005037, NM_015869, NM_138711, NM_138712, NM_001354666, NM_001354667, NM_001354668, NM_001354669, NM_001354670, NM_138712.1, NM_138712.2, NM_138712.3, NM_138711.1, NM_138711.2, NM_138711.3, NM_005037.1, NM_005037.2, NM_005037.3, NM_005037.4, NM_005037.5, NM_015869.1, NM_015869.2, NM_015869.3, NM_015869.4, BC006811, BM923992, NM_138712.4, NM_015869.5, NM_138711.4, NM_005037.6
UniProt ID P37231
Summary This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

TGFβ can stimulate the p(38)/β-catenin/PPARγ signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells)
Lin, Hsu, Wu et al
Clin. Exp. Metastasis (2014)
Cited by 36
AI Summary: OriGene contributed to this study by providing shRNA constructs against human PPARγ (carried by the pRS retroviral vector), which were used to block PPARγ expression and investigate its role in TGFβ-induced EMT, invasion, and migration of H460 non-small cell lung cancer cells.
Snippet: Immunodetection was viewed using ECL substrate kit. Blocking of PPARγ expression by shRNA transfection. One set of shRNA constructs against human PPARγ carried by pRS retroviral vector was purchased from OriGene (Rockville, MD, USA). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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