PPAR alpha (PPARA) Human shRNA Plasmid Kit (Locus ID 5465)
SKU
TR320458
PPARA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 5465 |
|---|---|
| Synonyms | hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | PPARA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5465). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC000052, NM_001001928, NM_001001929, NM_001001930, NM_005036, NM_032644, NM_005036.1, NM_005036.2, NM_005036.3, NM_005036.4, NM_001001928.1, NM_001001928.2, NM_001001929.2, NM_001001930.2, NM_032644.3, BC004162, BC009069, BC071932, NM_001362872, NM_001362873, NM_005036.6, NM_001001928.3 |
| UniProt ID | Q07869 |
| Summary | Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. provided by RefSeq, Jul 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels
Siong Tan, Anjum, Shen et al
Autophagy (2019) 15 (8), 1455-1459 DOI: 10.1080/15548627.2019.1609847
Siong Tan, Anjum, Shen et al
Autophagy (2019) 15 (8), 1455-1459 DOI: 10.1080/15548627.2019.1609847
AI Summary: OriGene contributed to this paper by providing the Ppara (NM_011144) plasmid, which was used to study the effects of ectopic PPARA induction on peroxisomal gene expression following lysosomal inhibition.
Snippet: y (SAB2500781) were purchased from SIGMA-ALDRICH. Anti-PPARA antibody (PA1-822A), LysoTracker Red DND-99 (L7528) and DMEM-F12 (11330057) were from ThermoFisher Scientific. Anti-CPT1A (ab128568), anti-GAPDH (ab9485) and anti-ACOX1 (ab9964) antibodies were from ABCAM. Ppara (NM_011144) plasmid was from ORIGENE, GFP-PGC1 was a gift from Bruce Spiegelman (Addgene, 4)
Showing 1-1 of 1 papers.
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