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Eph receptor A2 (EPHA2) Human shRNA Plasmid Kit (Locus ID 1969)

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SKU
TR320327
EPHA2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 1969
Synonyms ARCC2; CTPA; CTPP1; CTRCT6; ECK
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components EPHA2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1969). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_004431, NM_001329090, NM_004431.1, NM_004431.2, NM_004431.3, NM_004431.4, BC037166, BC037166.2, BC008655, NM_004431.5
UniProt ID P29317
Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.provided by RefSeq, May 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer
Buraschi, Neill, Xu et al
Matrix Biol. (2020)
Cited by 35
AI Summary: OriGene's pRS-shScr (scrambled shRNA) and pRS/shEphA2 plasmids were used to generate UMUC-3 bladder cancer cell lines with stable EphA2 depletion, enabling the study to demonstrate the critical role of the progranulin/EphA2 axis in promoting bladder cancer cell motility, growth, and drug resistance.
Snippet: Cell lines (UMUC-3) stably depleted of endogenous EphA2 were generated by transfecting the pRS-shScr (scrambled shRNAs) and pRS/shEphA2 plasmids expressing shRNAs against human EphA2 (OriGene Technologies, Inc.) using the TransIT -Prostate Transfection
EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma
Garcia-Monclús, López-Alemany, Almacellas-Rabaiget et al
Int. J. Cancer (2018) 143 (5), 1188-1201 DOI: 10.1002/ijc.31405
AI Summary: OriGene products contributed to this study by providing the pCMV6-EphA2 Myc-DKK tagged vector (#RC205725) for EphA2 overexpression and the pRS-shEphA2 vector (#TR320327) for EphA2 silencing, enabling the researchers to investigate the role of EphA2 in Ewing sarcoma cell behavior and metastasis.
Snippet: RH1 transfected cells stably expressing pCMV6-EphA2 Myc-DKK tagged vector (Origene #RC205725) were selected with 0.6 mg/mL of A673 and TC252 cells stably transfected with pRS- shEphA2 vector (Origene #TR320327) were selected with 0.5 µg/mL and 0.2
A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target
Tanaka, Yamada, Kuroki et al
Transl Oncol (2017) 10 (4), 476-484 DOI: 10.1016/j.tranon.2017.04.001
AI Summary: OriGene’s short hairpin RNA (shRNA) constructs were used in this study to facilitate gene silencing experiments, contributing to the identification and validation of cancer targets such as EphA2.
Snippet: purchased. Small interfering RNA (siRNA) oligonucleotides were obtained from Ambion Inc. (Austin, TX). Short hairpin RNA (shRNA) constructs were obtained from OriGene Technologies, Inc. (Rockville, MD). Cell Lines. The ... All 4 versions Cite SaveSaving
FigureFigureFigure
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma
Liu, Park, Lai et al
Cancer Res (2006) 66 (22), 10815-23 DOI: 10.1158/0008-5472.CAN-06-1408
AI Summary: In this study, OriGene products such as the EphA2 cDNA clone (OriGene, SC119989) and EphA2 shRNA plasmids (OriGene, TL313870) were used for gene overexpression and knockdown experiments to validate the functional role of EphA2 in glioblastoma cell proliferation and tumor growth.
Showing 1-4 of 4 papers.
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