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Chk1 (CHEK1) Human shRNA Plasmid Kit (Locus ID 1111)

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SKU
TR320302
CHEK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 1111
Synonyms CHK1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CHEK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1111). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001114121, NM_001114122, NM_001244846, NM_001274, NM_001330427, NM_001330428, NR_045204, NR_045205, NM_001274.1, NM_001274.3, NM_001274.4, NM_001274.5, NM_001114122.1, NM_001114122.2, NM_001114121.1, NM_001114121.2, NM_001244846.1, BC017575, BC017575.1, BC004202, BM455102
UniProt ID O14757
Summary The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Oct 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma
Bai, Wang, Huo et al
Transl Oncol (2017) 11 (1), 140-146 DOI: 10.1016/j.tranon.2017.11.007
AI Summary: OriGene's shCHEK1 lentivirus particles (pGFP-C-shLenti, TR320302) were used in this study to knock down CHEK1 expression in glioblastoma cells, enabling the researchers to investigate CHEK1's role in tumor proliferation and radio resistance.
Snippet: 500-0006), BSA used in Bradford assay (BioLabs, B9001S), PageRuler plus prestained protein (Thermo scientific, 26619), iScript Reverse Transcription supermix for qRT-PCR (Bio-rad, 170-8841), shCHEK1 lentivirus particles (pGFP-C-shLenti, Origene, TR320302
Translational Oncology Volume 11 Number
Bai, Wang, Huo et al
Translational Oncology (2018)
AI Summary: OriGene contributed to this study by providing the shCHEK1 lentivirus particles (pGFP-C-shLenti, TR320302) used for gene silencing experiments.
Snippet: 500-0006), BSA used in Bradford assay (BioLabs, B9001S), PageRuler plus prestained protein (Thermo scientific, 26619), iScript Reverse Transcription supermix for qRT-PCR (Bio-rad, 170-8841), shCHEK1 lentivirus particles (pGFP-C-shLenti, Origene, TR320302
Showing 1-2 of 2 papers.
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