OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Cyclin D3 (CCND3) Human shRNA Plasmid Kit (Locus ID 896)

Be the first to review this product
SKU
TR320286
CCND3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

Frequently Bought Together (2)

TA350646 Rabbit Polyclonal Anti-CCND3 Antibody
100 ul
$205.00
TF81001 TurboFectin Transfection Reagent (1 mL in 1 vial)
1 ml in 1 vial
$530.00

Other products for "Cyclin D3 or NM_001136017"

Specifications
Specifications
Product Data
Locus ID 896
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CCND3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 896). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001136017, NM_001136125, NM_001136126, NM_001287427, NM_001287434, NM_001760, NM_001760.1, NM_001760.2, NM_001760.3, NM_001760.4, NM_001136125.1, NM_001136125.2, NM_001136017.1, NM_001136017.2, NM_001136017.3, NM_001136126.1, NM_001136126.2, NM_001287434.1, NM_001287427.1, BC011616, BC011616.2, NM_001760.5
UniProt ID P30281
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

L-arginine availability regulates T-lymphocyte cell-cycle progression
Rodriguez, Quiceno, Ochoa
Blood (2007) 109 (4), 1568-73 DOI: 10.1182/blood-2006-06-031856
Cited by 922
AI Summary: In this paper, OriGene products—specifically the cyclin D3 siRNA (SR303345) and cdk4 siRNA (SR303070)—were used to silence gene expression in T cells, demonstrating that knockdown of cyclin D3 or cdk4 mimicked the cell cycle arrest observed during L-arginine starvation, thereby helping to elucidate the molecular mechanisms by which L-arginine regulates T-lymphocyte cell-cycle progression.
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products