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B Raf (BRAF) Human shRNA Plasmid Kit (Locus ID 673)

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SKU
TR320276
BRAF - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 673
Synonyms B-raf; B-RAF1; BRAF1; NS7; RAFB1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BRAF - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 673). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_004333, NM_001354609, NR_148928, NM_004333.1, NM_004333.2, NM_004333.3, NM_004333.4, BC101757, BC101757.1, BC038966, BC112079, BM263585, NM_004333.6
UniProt ID P15056
Summary This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer
Ban, Kim, Kim et al
Endocrinol Metab (Seoul) (2021) 36 (1), 96-105 DOI: 10.3803/EnM.2020.819
AI Summary: OriGene contributed to this study by providing the BRAF-specific short hairpin RNA (shRNA) and a scrambled negative control, which were used to manipulate BRAF expression in thyroid cell lines to assess its effect on LDHA expression.
Snippet: μm filter. The purified lentiviral particles were used to infect Nthy-ori 3-1 cells. The BRAF-specific short hairpin RNA (shRNA) and a scrambled negative control were purchased from OriGene (Rockville, MD, USA). Cells were
FigureFigureFigure
Showing 1-1 of 1 papers.
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