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Bcl x (BCL2L1) Human shRNA Plasmid Kit (Locus ID 598)

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SKU
TR320077
BCL2L1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "Bcl x or NM_001191"

Specifications
Specifications
Product Data
Locus ID 598
Synonyms Bcl-X; BCL-XL/S; BCL2L; BCLX; PPP1R52
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BCL2L1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 598). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001191, NM_001317919, NM_001317920, NM_001317921, NM_001322239, NM_001322240, NM_001322242, NM_138578, NR_134257, NM_138578.1, NM_138578.2, NM_001191.1, NM_001191.2, NM_001191.3, BC019307, BC019307.1, BM554265, NM_001191.4, NM_138578.3
UniProt ID Q07817
Summary The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. provided by RefSeq, Dec 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium
Shukla, Tyagi, Chandrasekaran et al
Sci Adv (2025) 11 (24), eadv8640 DOI: 10.1126/sciadv.adv8640
Cited by 6
AI Summary: OriGene shRNA products targeting PLAC8 (TL302451), NF-κB (TL302038), and BCL-xL (TR320077) were used to generate stable knockdown prostate cell lines, enabling the study of how these genes interact to regulate autophagy and survival in cadmium-transformed cells.
Snippet: sformed RWPE-1 cells with stable PLAC8 (TL302451, Origene), NF-κB (TL302038, Origene), or BCL-xL (TR320077, Origene) knockdown were generated by shRNA and antibiotic selection. BCL-xL (6362, Cell Signaling) or a control small interfering RNA was used for transient transfection. For overex
FigureFigureFigure
Showing 1-1 of 1 papers.
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