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RAC2 Human shRNA Plasmid Kit (Locus ID 5880)

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SKU
TR318935
RAC2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 5880
Synonyms EN-7; Gx; HSPC022; IMD73A; IMD73B; IMD73C; p21-Rac2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components RAC2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5880). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_002872, NM_014029, NM_002872.1, NM_002872.2, NM_002872.3, NM_002872.4, BC001485, BC001485.2, BC018735, BC051899, NM_002872.5
UniProt ID P15153
Summary This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. provided by RefSeq, Jul 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors
Nieborowska-Skorska, Kopinski, Ray et al
Blood (2012) 119 (18), 4253-63 DOI: 10.1182/blood-2011-10-385658
Cited by 189
AI Summary: OriGene products contributed to this study by providing the Rac2 shRNA (OriGene, catalog no. TL313482) used for gene knockdown experiments to investigate the role of Rac2 in mitochondrial ROS generation and genomic instability in chronic myeloid leukemia stem and progenitor cells.
Showing 1-1 of 1 papers.
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