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TAB2 Human shRNA Plasmid Kit (Locus ID 23118)

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SKU
TR316993
TAB2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 23118
Synonyms CHTD2; MAP3K7IP2; TAB-2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TAB2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 23118). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001292034, NM_001292035, NM_015093, NM_145342, NR_125861, NM_015093.1, NM_015093.2, NM_015093.3, NM_015093.4, NM_015093.5, NM_001292035.1, NM_001292035.2, NM_001292034.1, NM_001292034.2, BC035910, BC035910.2, BC041998, BM661637, NM_001369506, NM_001292035.3, NM_001292034.3
UniProt ID Q9NYJ8
Summary The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. provided by RefSeq, May 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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