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IGFBP2 Human shRNA Plasmid Kit (Locus ID 3485)

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SKU
TR316590
IGFBP2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 3485
Synonyms IBP2; IGF-BP53
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IGFBP2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3485). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000597, NM_001313990, NM_001313992, NM_001313993, NM_000597.1, NM_000597.2, BC004312, BC004312.1, BC009902, BC012769, BC071967
UniProt ID P18065
Summary The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Novel anti IGFBP2 single chain variable fragment inhibits glioma cell migration and invasion
Patil, Railkar, Swain et al
J Neurooncol (2015) 123 (2), 225-35 DOI: 10.1007/s11060-015-1800-7
Cited by 35
AI Summary: In this study, OriGene’s human recombinant IGFBP2 protein (Cat# TP301079) was used as the target antigen for screening phage display libraries to identify single chain variable fragments (scFvs) that specifically bind and inhibit IGFBP2-mediated glioma cell migration and invasion.
Regulation of protumorigenic pathways by insulin like growth factor binding protein2 and its association along with β-catenin in breast cancer lymph node metastasis
Sehgal, Kumar, Praveen Kumar et al
Mol. Cancer (2013) 12, 63 DOI: 10.1186/1476-4598-12-63
Cited by 36
AI Summary: OriGene products, specifically the IGFBP2 shRNA expression vector (Cat no. TR316590) and the empty vector (Cat no. TR20003), were used to stably knock down IGFBP2 expression in breast cancer cells, enabling the study of IGFBP2’s role in regulating β-catenin and its association with breast cancer metastasis.
Snippet: In brief, breast cancer cells were transfected with IGFBP2 shRNA expression vector (Origene, Cat no. TR316590) or empty vector (Origene, Cat no. TR20003) and 48 hrs after transfection puromycin (1 μg/ml, Calbiochem) was
Showing 1-2 of 2 papers.
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