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SDHA Human shRNA Plasmid Kit (Locus ID 6389)

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SKU
TR315539
SDHA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 6389
Synonyms CMD1GG; FP; MC2DN1; NDAXOA; PGL5; SDH1; SDH2; SDHF
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SDHA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 6389). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001294332, NM_004168, NM_001330758, NM_004168.1, NM_004168.2, NM_004168.3, NM_001294332.1, BC001380, BC001380.2, BC004328, BC041016, NM_004168.4
UniProt ID P31040
Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jun 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Complex I and II are required for normal mitochondrial Ca2+ homeostasis
Jaña, Bustos, Rivas et al
Mitochondrion (2019) 49, 73-82 DOI: 10.1016/j.mito.2019.07.004
AI Summary: OriGene’s shRNA construct in retroviral untagged vector (OriGene™ TR315539) was used to knock down SDHA expression, enabling the study of its role in mitochondrial calcium homeostasis.
Snippet: For SDHA knockdown (SDHA-KD) cells, shRNA construct in retroviral untagged vector was used (Origene TR315539). Transfection was done with FuGENE in reduced serum media for 24 h and selected with puromycin. 2.3. Western blotting
Showing 1-1 of 1 papers.
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