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PARP1 Human shRNA Plasmid Kit (Locus ID 142)

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SKU
TR315488
PARP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 142
Synonyms ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PARP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 142). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001618, NM_001618.1, NM_001618.2, NM_001618.3, BC037545, BC037545.1, BC008660, BC014206, BC018620, BC021045
UniProt ID P09874
Summary This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1
Hulse, Caruso, Madzo et al
PLoS Pathog. (2018) 14 (11), e1007394 DOI: 10.1371/journal.ppat.1007394
AI Summary: OriGene’s shPARP1 plasmid (TR315488) and sh-non-effective scrambled control plasmid (TR30021) were used to generate lentiviral particles for PARP1 knockdown experiments, enabling the authors to study the role of PARP1 in LMP1-mediated gene regulation.
Snippet: shPARP1 and sh-non-effective scrambled plasmids were bought from Origene (TR315488 and TR30021). Lentiviral particles were generated by transfecting 293T cells with pLKO.1-shPARP1 or scrambled shRNA, the psPAX2 (plasmid number 12260;Addgene) packaging plasmid, and the pMD2.G envelope plasmid (plasmid number 12259;Addgene) according to the Addgene protocol. … DG75 cells were infected with two separate lentivirus expressing shPARP1 (Origene TR315488A-B), or the sh control vector freshly generated from 293T cells
Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism
Nocchi, Tomasetti, Amati et al
J. Biol. Chem. (2011) 286 (22), 19478-88 DOI: 10.1074/jbc.M110.217331
Cited by 7
AI Summary: OriGene’s empty pRS plasmid was used as a control in experiments involving PARP1 gene silencing, helping to elucidate the epigenetic regulation of thrombomodulin expression in malignant mesothelioma.
Snippet: Silencing of the TM gene promoter has been implicated in the down-regulation of TM synthesis, and it was found that methylation of the promoter ... PARP1 targeting sequence of TAC CAT CCA GGC TGC TTT GTC AAG AAC AG or 1 μg of empty pRS plasmid (OriGene) using the
Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression
Kannan, Fang, Song et al
Blood (2011) 117 (10), 2891-900 DOI: 10.1182/blood-2009-12-253419
Cited by 66
AI Summary: OriGene products contributed to this study by providing the HES1 cDNA clone (OriGene, SC119234), which was used to investigate the role of HES1 in mediating PARP1 activation and apoptosis in B-cell acute lymphoblastic leukemia.
Showing 1-3 of 3 papers.
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