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AGXT Human shRNA Plasmid Kit (Locus ID 189)

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SKU
TR314885
AGXT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 189
Synonyms AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components AGXT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 189). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000030, NM_016236, NM_000030.1, NM_000030.2, BC132819, NM_000030.3
UniProt ID P21549
Summary This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis
Pagliarini, Castello, Napolitano et al
Cell Rep (2016)
Cited by 36
AI Summary: OriGene’s AGXT shRNA plasmid was used to transfect Huh-7 liver cells, enabling the researchers to downregulate AGT expression and model AGT deficiency in vitro for their studies on liver metabolism in primary hyperoxaluria type I.
Snippet: … Cells were transfected with a plasmid containing a small hairpin RNA (shRNA) for AGXT gene (OriGene) using TransIT-LT1 transfection reagent according to the manufacturer’s instructions (Mirus). … Downregulation of AGT was shown by western blotting with primary rabbit polyclonal anti-AGXT (Sigma) and primary monoclonal anti-calnexin antibody (Enzo Life Sciences). …
Showing 1-1 of 1 papers.
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