ALOX15 Human shRNA Plasmid Kit (Locus ID 246)
SKU
TR314822
ALOX15 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 246 |
|---|---|
| Synonyms | 12-LOX; 15-LOX; 15-LOX-1; LOG15 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | ALOX15 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 246). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001140, NM_001140.1, NM_001140.2, NM_001140.3, BC029032, BC029032.1 |
| UniProt ID | P16050 |
| Summary | This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. provided by RefSeq, Aug 2017 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion
Moussalli, Wu, Zuo et al
Cancer Prev Res (Phila) (2011) 4 (12), 1961-72 DOI: 10.1158/1940-6207.CAPR-10-0280
Moussalli, Wu, Zuo et al
Cancer Prev Res (Phila) (2011) 4 (12), 1961-72 DOI: 10.1158/1940-6207.CAPR-10-0280
Cited by 3
AI Summary: OriGene's PRS 15-LOX-1 shRNA vectors were used in this study to specifically downregulate 15-LOX-1 expression in cancer cells, enabling the authors to investigate the role of 15-LOX-1 loss in blocking terminal cell differentiation.
Snippet: PRS 15-LOX-1 shRNA vectors (OriGene) containing 29-bp shRNA forward and reverse complementary sequences that are connected by a 7-bp loop and driven by the human U6 promoter were designed to target human 15-LOX-1. The vectors were named for the various
Showing 1-1 of 1 papers.
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