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ATF6 Human shRNA Plasmid Kit (Locus ID 22926)

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SKU
TR314613
ATF6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "ATF6 or NM_007348"

Specifications
Specifications
Product Data
Locus ID 22926
Synonyms ACHM7; ATF6A
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components ATF6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 22926). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_007348, NM_007348.1, NM_007348.2, NM_007348.3, BC014969, BC071997, BC166676, BM683233, NM_007348.4
UniProt ID P18850
Summary This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. provided by RefSeq, Aug 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Insulin demand regulates β cell number via the unfolded protein response
Sharma, O'Donnell, Stamateris et al
J. Clin. Invest. (2015) 125 (10), 3831-3846 DOI: 10.1172/JCI79264
AI Summary: OriGene’s sh-ATF6 and sh-IRE1 short hairpin RNA products were used to knock down ATF6 and IRE1 expression in pancreatic islet cells, enabling the study of how these unfolded protein response regulators affect β cell proliferation in response to insulin demand.
Snippet: … Plasmids were obtained from Addgene (ATF6α, IRE1α, and sXbp) or OriGene (sh-ATF6 and sh-IRE1). …
Showing 1-1 of 1 papers.
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