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BAG3 Human shRNA Plasmid Kit (Locus ID 9531)

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SKU
TR314524
BAG3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 9531
Synonyms BAG-3; BIS; CAIR-1; MFM6
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BAG3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 9531). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_004281, NM_004281.1, NM_004281.2, NM_004281.3, BC006418, BC006418.1, BC014656, BC107786, NM_004281.4
UniProt ID O95817
Summary BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy
d'Avenia, Citro, De Marco et al
Cell Death Dis (2015) 6, e1948 DOI: 10.1038/cddis.2015.280
Cited by 54
AI Summary: OriGene’s BAG3-human 29mer shRNA retroviral construct (Cat# specified) was used in this study to knock down BAG3 expression in cardiomyocytes, enabling investigation of BAG3’s role in the molecular mechanisms underlying Takotsubo cardiomyopathy.
Snippet: BAG3 expression, HCM cells were seeded 60 000 cells/well (6-well plates) and 4 h later transfected by using 2 μl of X-treme Gene 9 reagent (Roche, Indianapolis, IN, USA) with 0.5 μg/well of BAG3-human 29mer shRNA retroviral construct (gene ID=9531;Origene Cat ... Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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