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CBX4 Human shRNA Plasmid Kit (Locus ID 8535)

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SKU
TR314171
CBX4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 8535
Synonyms NBP16; PC2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CBX4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8535). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC014967, NM_003655, NM_003655.1, NM_003655.2, BC014967.1, NM_003655.3
UniProt ID O00257
Summary E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage
Ismail, Gagné, Caron et al
Nucleic Acids Res. (2012) 40 (12), 5497-510 DOI: 10.1093/nar/gks222
Cited by 144
AI Summary: OriGene contributed to this study by providing control and CBX4 shRNA plasmids, as well as by generating custom shRNA constructs against PIAS1 and PIAS4 using their exact shRNA service, which were used to investigate the roles of these genes in the DNA damage response.
Snippet: Control and two different CBX4 shRNA plasmids were obtained from Origene. ... For PIAS1 or PIAS4 shRNA, a previously described shRNA against PIAS1 or against PIAS4 was cloned into separate eGFP vectors (29) using the exact shRNA service at Origene.
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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