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CCR4 Human shRNA Plasmid Kit (Locus ID 1233)

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SKU
TR314127
CCR4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 1233
Synonyms CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CCR4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1233). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_005508, NM_005508.1, NM_005508.2, NM_005508.3, NM_005508.4, BC071751, BC069139, BC074935, NM_005508.5
UniProt ID P51679
Summary The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
Berlato, Khan, Schioppa et al
J. Clin. Invest. (2017) 127 (3), 801-813 DOI: 10.1172/JCI82976
AI Summary: OriGene products contributed to this study by providing commercially available shRNAs (TR314127 for human CCR4 and TR500386 for mouse CCR4) used to specifically target and knock down CCR4 expression in experimental models.
Snippet: Commercially available shRNAs, based on the pRS vector, were purchased from Origene Technologies. Four non-overlapping sequences were provided to target human (TR314127) and mouse (TR500386) CCR4
Showing 1-1 of 1 papers.
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