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CCR5 Human shRNA Plasmid Kit (Locus ID 1234)

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SKU
TR314126
CCR5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 1234
Synonyms CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CCR5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1234). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000579, NM_001100168, NM_001100168.1, NM_000579.1, NM_000579.2, NM_000579.3, BC038398
UniProt ID P51681
Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jul 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Enabling Survival of Transplanted Neural Precursor Cells in the Ischemic Brain
Wang, Zheng, Tan et al
Adv Sci (Weinh) (2023) 10 (33), e2302527 DOI: 10.1002/advs.202302527
Cited by 12
AI Summary: OriGene products, specifically the Human CCR5 29mer shRNA plasmid (CAT#: TR314126) and the non-effective 29-mer scrambled shRNA cassette in pRS Vector (CAT#: TR30012), were used to generate lentiviral shRNAs for molecular analysis of CCR5 function in transplanted neural precursor cells in this study.
Snippet: … Lentivirus Production Human CCR5 29mer shRNA plasmids (pRS_hU6_CCR5shRNA_SV40_Puro) and non‐effective 29‐mer scrambled shRNA cassette in pRS Vector were obtained from OriGene (CAT#: TR314126, CAT#: TR30012). … HEK 293FT cells were cultured in DMEM;Human CCR5 29mer shRNA plasmids (pRS_hU6_CCR5shRNA_SV40_Puro) and non-effective 29-mer scrambled shRNA cassette in pRS Vector were obtained from OriGene (CAT#: TR314126, CAT#: TR30012)
Showing 1-1 of 1 papers.
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