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CPT1A Human shRNA Plasmid Kit (Locus ID 1374)

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SKU
TR313747
CPT1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "CPT1A or NM_001031847"

Specifications
Specifications
Product Data
Locus ID 1374
Synonyms CPT1; CPT1-L; L-CPT1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CPT1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1374). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001031847, NM_001876, NM_001031847.1, NM_001031847.2, NM_001876.1, NM_001876.2, NM_001876.3, BC000185, NM_001876.4
UniProt ID P50416
Summary The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance
Fontana, Belisario, Giannotta et al
Drug Resist Updat (2026) 89, 101462 DOI: 10.1016/j.drup.2026.101462
Cited by 1
AI Summary: OriGene products, specifically the GFP-lentiviral shRNA plasmids targeting CPT1A (TR313747), LAP (TL320301), ABCB1 (TL315032V), ABCC1 (TL306920V), ABCC2 (TL315026V), and a scrambled control (TR30021), were used for gene silencing to investigate the roles of these genes in chemoresistance and metabolic reprogramming in NSCLC cells.
Snippet: For gene silencing, 1 × 105 cells were transduced with 1 μg of a GFP-lentiviral plasmid containing a non-relevant 29-mer scrambled shRNA cassette (TR30021), a sequence targeting CPT1A (TR313747), LAP (TL320301), ABCB1 (TL315032V), ABCC1 (TL306920V) or ABCC2 (TL315026V;all from Origene, Rockville, MD)
Showing 1-1 of 1 papers.
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