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CTCF Human shRNA Plasmid Kit (Locus ID 10664)

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SKU
TR313675
CTCF - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "CTCF or NM_001191022"

Specifications
Specifications
Product Data
Locus ID 10664
Synonyms CFAP108; FAP108; MRD21
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CTCF - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 10664). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001191022, NM_006565, NM_006565.1, NM_006565.2, NM_006565.3, NM_001191022.1, BC014267, BC014267.2, NM_001363916, NM_006565.4
UniProt ID P49711
Summary This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Identification of CTCF as a master regulator of the clustered protocadherin genes
Golan-Mashiach, Grunspan, Emmanuel et al
Nucleic Acids Res. (2012) 40 (8), 3378-91 DOI: 10.1093/nar/gkr1260
Cited by 66
AI Summary: In this study, OriGene's CTCF siRNA (cat # SR307273) was used to deplete CTCF in SH-SY5Y cells, enabling the authors to assess CTCF's role in regulating protocadherin gene expression.
Snippet: The 20-bp-long SSE is essential for transcription and can activate transcription only in the presence of the CSE ... effect of CTCF depletion on the activity of the reporter gene, SH-SY5Y cells were grown on 10-well plates and transfected with CTCF siRNA (Origene, cat # SR307273
FigureFigureFigure
Showing 1-1 of 1 papers.
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