OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

CYBB Human shRNA Plasmid Kit (Locus ID 1536)

Be the first to review this product
SKU
TR313616
CYBB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

Frequently Bought Together (2)

TA351456 Rabbit Polyclonal Anti-CYBB Antibody
100 ul
$205.00
TF81001 TurboFectin Transfection Reagent (1 mL in 1 vial)
1 ml in 1 vial
$530.00

Other products for "CYBB or NM_000397"

Specifications
Specifications
Product Data
Locus ID 1536
Synonyms AMCBX2; CGD; CGDX; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CYBB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1536). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000397, NM_000397.1, NM_000397.2, NM_000397.3, BC032720, BC032720.1, NM_000397.4
UniProt ID P04839
Summary Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins
Bertoni, Giuliano, Galgani et al
J. Biol. Chem. (2011) 286 (6), 4727-41 DOI: 10.1074/jbc.M110.156521
Cited by 13
AI Summary: OriGene’s pRS shRNA expression vector encoding a 29-mer shRNA against CYBB gp91 phox was used in this study to selectively silence the NADPH oxidase subunit gp91, helping to demonstrate its role in polyQ-expanded protein-induced cellular stress and DNA damage.
Snippet: a synthetic fusion protein (HA-43Q-GFP) accumulate nuclear aggregates, inhibit cAMP- and NGF-dependent transcription, and slow down differentiation. ... 5) and 2.5 μg of pRS shRNA expression vector encoding a 29-mer shRNA against CYBB gp91 phox (OriGene technologies
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products