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DIO1 Human shRNA Plasmid Kit (Locus ID 1733)

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SKU
TR313473
DIO1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 1733
Synonyms 5DI; TXDI1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components DIO1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1733). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000792, NM_001039715, NM_001039716, NM_213593, NM_001324316, NR_136692, NR_136693, NM_001039716.1, NM_001039716.2, NM_000792.1, NM_000792.2, NM_000792.3, NM_000792.4, NM_000792.5, NM_000792.6, NM_213593.1, NM_213593.2, NM_213593.3, NM_001039715.1, NM_001039715.2, BC017955, BC107170, BC107171, NM_001039715.3, NM_000792.7, NM_213593.5, NM_001039716.3
UniProt ID P49895
Summary The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Jun 2018
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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