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DKK1 Human shRNA Plasmid Kit (Locus ID 22943)

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SKU
TR313465
DKK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 22943
Synonyms DKK-1; SK
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components DKK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 22943). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC001539, NM_012242, NM_012242.1, NM_012242.2, BC001539.2, NM_012242.4
UniProt ID O94907
Summary This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. provided by RefSeq, Sep 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells
Hussain, Rao, Humphries et al
Cancer Res (2009) 69 (8), 3570-8 DOI: 10.1158/0008-5472.CAN-08-2807
AI Summary: In this study, OriGene's EZH2 (SR321752) and SirT1 (SR304170) siRNA products were used to knock down gene expression, helping to demonstrate that these proteins are involved in tobacco smoke-induced repression of Dickkopf-1 in lung cancer cells.
FigureFigure
Showing 1-1 of 1 papers.
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