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DNMT1 Human shRNA Plasmid Kit (Locus ID 1786)

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SKU
TR313404
DNMT1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 1786
Synonyms ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components DNMT1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1786). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001130823, NM_001318730, NM_001318731, NM_001379, NM_001379.1, NM_001379.2, NM_001379.3, NM_001130823.1, NM_001130823.2, BC092517, BC126227, BC144093, NM_001130823.3
UniProt ID P26358
Summary This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

CD66+ cells in cervical pre-cancers are partially differentiated progenitors with neoplastic traits
Pattabiraman, Hong, Gunasekharan et al
Cancer Res. (2014)
AI Summary: OriGene’s shRNA against DNMT1 was used in this study to investigate the role of DNMT1 in CD66+ cervical pre-cancer cells, helping to elucidate the relationship between DNMT1 expression and neoplastic traits.
Snippet: Further, CaSki ex-plants in mice generate tumours as per previous reports (10). CIN-612 cells were transduced as described earlier (30) with virions carrying shRNAs against DNMT1 (Origene for Supplementary Fig. 3G, Page 5. 5 and plasmids described in (30) Fig ... Cite SaveSaving
Showing 1-1 of 1 papers.
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