DPM1 Human shRNA Plasmid Kit (Locus ID 8813)

SKU TR313384

DPM1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 8813
• Synonyms: CDGIE; MPDS
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: DPM1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8813). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001317034, NM_001317035, NM_001317036, NM_003859, NR_133648, NM_003859.1, NM_003859.2, BC007073, BC007073.1, BC008427, BC008466, BC016322, BM922866, NM_003859.3
• UniProt ID: O60762
• Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient