CSB (ERCC6) Human shRNA Plasmid Kit (Locus ID 2074)
SKU
TR313176
ERCC6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 2074 |
|---|---|
| Synonyms | ARMD5; CKN2; COFS; COFS1; CSB; CSB-PGBD3; POF11; RAD26; UVSS1 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | ERCC6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2074). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_000124, NM_001277058, NM_001277059, NM_001346440, NM_000124.1, NM_000124.2, NM_000124.3, NM_001277058.1, NM_001277059.1, BC127104, BC034479, NM_001277058.2, NM_001277059.2, NM_000124.4 |
| UniProt ID | Q03468 |
| Summary | This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. provided by RefSeq, Mar 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane
Aamann, Sorensen, Hvitby et al
FASEB J (2010) 24 (7), 2334-46 DOI: 10.1096/fj.09-147991
Aamann, Sorensen, Hvitby et al
FASEB J (2010) 24 (7), 2334-46 DOI: 10.1096/fj.09-147991
Cited by 142
AI Summary: In this study, OriGene products—including the anti-CSB/ERCC6 antibody (TA323038) and CSB/ERCC6 shRNA (TF311647)—were used to detect and manipulate CSB protein expression, enabling the authors to investigate the role of CSB in mitochondrial DNA repair and stability.
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase
Muftuoglu, de Souza-Pinto, Dogan et al
J Biol Chem (2009) 284 (14), 9270-9 DOI: 10.1074/jbc.M807006200
Muftuoglu, de Souza-Pinto, Dogan et al
J Biol Chem (2009) 284 (14), 9270-9 DOI: 10.1074/jbc.M807006200
AI Summary: In this study, OriGene products—specifically, CSB shRNA (OriGene, Cat# TL313089) and NEIL1 shRNA (OriGene, Cat# TL313282)—were used to deplete CSB and NEIL1 in HeLa cells to investigate their roles in the repair of formamidopyrimidines, demonstrating that knockdown of these proteins strongly inhibited DNA repair.
Showing 1-2 of 2 papers.
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