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FANCD2 Human shRNA Plasmid Kit (Locus ID 2177)

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SKU
TR313068
FANCD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 2177
Synonyms FA-D2; FA4; FACD; FAD; FAD2; FANCD
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FANCD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2177). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001018115, NM_001319984, NM_033084, NM_033084.1, NM_033084.2, NM_033084.3, NM_033084.4, NM_001018115.1, NM_001018115.2, BC013582, BC038666, BC156799, NM_033084.6, NM_001018115.3
UniProt ID Q9BXW9
Summary The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies
Spardy, Duensing, Hoskins et al
Cancer Res (2008) 68 (23), 9954-63 DOI: 10.1158/0008-5472.CAN-08-0224
AI Summary: In this study, OriGene’s FANCD2 shRNA (OriGene, Cat# TF314527) was used to knock down FANCD2 expression, enabling the authors to demonstrate FANCD2’s critical role in telomere maintenance in cells utilizing the alternative lengthening of telomeres (ALT) pathway.
FigureFigure
Showing 1-1 of 1 papers.
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