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KGF (FGF7) Human shRNA Plasmid Kit (Locus ID 2252)

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SKU
TR312988
FGF7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "KGF or NM_002009"

Specifications
Specifications
Product Data
Locus ID 2252
Synonyms HBGF-7; KGF
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FGF7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2252). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_002009, NM_002009.1, NM_002009.2, NM_002009.3, BC010956, NM_002009.4
UniProt ID P21781
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells
Cichon, Pickard, McDade et al
Oncotarget (2013) 4 (7), 1103-16
Snippet: interference: PTEN 5' TCC TGC AGA AAG ACT TGA AG 3'. shRNA targeting KGF was purchased from Origene (TR312988, puromycin ... RNA from cells and organotypic rafts was harvested using Trizol (Life Technologies, Paisley, UK), while RNA from tissues was extracted
FigureFigureFigure
Regulation of epithelial differentiation and proliferation by the stroma: a role for the retinoblastoma protein
Pickard, Cichon, Menges et al
J. Invest. Dermatol. (2012) 132 (12), 2691-9 DOI: 10.1038/jid.2012.201
Cited by 16
AI Summary: OriGene's shRNAs targeting KGF were used to reduce KGF levels in Rb-depleted fibroblasts, enabling the authors to demonstrate that KGF mediates the effects of stromal Rb on epithelial differentiation and proliferation.
Snippet: (b) Western blots confirming knockdown of Rb and p53 in human foreskin fibroblasts (HFFs) compared with scrambled short hairpin RNA ... in 400 μg ml –1 G418 or 20 μg ml –1 hygromycin for 2–4 days before transducing with shRNAs targeting KGF (Origene, Rockville, MD
FigureFigureFigure
Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion
Pickard, Cichon, Barry et al
EMBO J. (2012) 31 (14), 3092-103 DOI: 10.1038/emboj.2012.153
Cited by 35
AI Summary: OriGene products contributed to this study by providing shRNA targeting KGF (TR312988) and shRNA targeting Ets2 (TG320351), which were used to investigate the roles of these genes in stromal fibroblast-mediated epithelial cell invasion.
Snippet: measured in terms of frequency of events, area and depth of invasion (Figure 2D–F). There was a good agreement between ... shRNA targeting KGF were purchased from Origene (TR312988, puromycin selection, molecules 3 and 4) as were shRNA targeting Ets2 (TG320351
Showing 1-3 of 3 papers.
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