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FOXD3 Human shRNA Plasmid Kit (Locus ID 27022)

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SKU
TR312939
FOXD3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "FOXD3 or NM_012183"

Specifications
Specifications
Product Data
Locus ID 27022
Synonyms AIS1; Genesis; HFH2; VAMAS2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FOXD3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 27022). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_012183, NM_012183.1, NM_012183.2, BC172266, BC172572, NM_012183.3
UniProt ID Q9UJU5
Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. provided by RefSeq, Nov 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway
Li, Guo, Yang et al
Oncotarget (2017) 8 (3), 5048-5056 DOI: 10.18632/oncotarget.13790
Snippet: HCT116 and Caco-2 cells were purchased from ATCC. The stable cell lines were generated by integration of retroviral shRNA vectors specific for FOXD3 or a control gene from OriGene (Rockville, MD). All cell lines were cultured in DMEM supplemented with 10% fetal bovine serum (Gibco)
FigureFigureFigure
Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia
Chen, Raval, Johnson et al
Proc Natl Acad Sci U S A (2009) 106 (32), 13433-8 DOI: 10.1073/pnas.0906455106
Cited by 89
AI Summary: OriGene products contributed to this study by providing the Foxd3 cDNA clone (OriGene, MC205527), which was used to investigate the role of Foxd3 in transcriptional repression and epigenetic silencing during chronic lymphocytic leukemia progression in mice.
Showing 1-2 of 2 papers.
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