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FRMPD2 Human shRNA Plasmid Kit (Locus ID 143162)

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SKU
TR312922
FRMPD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 143162
Synonyms FERM and PDZ domain containing 2; MGC35285; MGC87776; MGC87777; MGC90186; PDZD5C; PDZ domain containing 5C; PDZK5C
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FRMPD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 143162). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001017929, NM_001018071, NM_001042512, NM_001318191, NM_152428, NR_033178, NM_001018071.1, NM_001018071.2, NM_001018071.3, NM_001042512.1, NM_001042512.2, NM_001017929.1, NM_152428.4, NM_152428.1, BC031614, BC040910, BC073954, BC144636, BC144639, BC156408, BC157131
UniProt ID Q68DX3
Summary This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. provided by RefSeq, Dec 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells
Stenzel, Fetzer, Heumann et al
J Cell Sci (2009) 122 (Pt 18), 3374-84 DOI: 10.1242/jcs.046854
Cited by 25
AI Summary: OriGene products contributed to this study by providing the FRMPD2 cDNA clone (Cat# RC217307) and specific anti-FRMPD2 antibodies (Cat# TA501271), which were used for protein expression and detection to investigate FRMPD2’s localization and function in epithelial cell polarization.
Showing 1-1 of 1 papers.
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