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HDAC1 Human shRNA Plasmid Kit (Locus ID 3065)

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SKU
TR312496
HDAC1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "HDAC1 or NM_004964"

Specifications
Specifications
Product Data
Locus ID 3065
Synonyms GON-10; HD1; KDAC1; RPD3; RPD3L1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components HDAC1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3065). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_004964, NM_004964.1, NM_004964.2, BC000301, BC000301.2, NM_004964.3
UniProt ID Q13547
Summary Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Chronic sun exposure is associated with distinct histone acetylation changes in human skin
Ding, Chen, Zeng et al
Br. J. Dermatol. (2017)
AI Summary: OriGene products—specifically the pCMV6-P300 expression vector and pRS-HDAC1 and pRS-SIRT1 shRNA vectors—were used in this study to manipulate gene expression and investigate the roles of P300, HDAC1, and SIRT1 in histone acetylation changes associated with chronic sun exposure in human skin.
Snippet: All recordings were made 48 hrs after transfection. Expression (pCMV6-P300) and shRNA (pRS-HDAC1, pRS-SIRT1) vectors were purchased from OriGene (MD, USA). 2.6. ChIP-chip ChIP analysis were performed according to the instructions provided by the EZ ChIP
Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases
Huang, Chen, Chou et al
Mol. Pharmacol. (2011) 79 (1), 197-206 DOI: 10.1124/mol.110.067702
Cited by 111
AI Summary: OriGene products contributed to this study by providing shRNA constructs targeting HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, which were used to investigate the roles of specific HDAC isozymes in regulating histone H3K4 methylation and demethylase expression.
Snippet: suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down-regulation of ... shRNA for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 were purchased from Origene, Inc.
Regulation of Nucleocytoplasmic Shuttling of the Transcriptional Regulator Human Mesoderm Induction Early Response 1 α in Breast Carcinoma Cells
Li
Thesis (2018)
Snippet: Plasmids containing ERα shRNA (Cat. No. TR320346), HDAC1 shRNA (Cat. No. TR312496), HDAC2 shRNA (Cat. No. TR312495) or a control scrambled shRNA (Cat. No. TR20003) were purchased from Origene Technologies, Inc
Showing 1-3 of 3 papers.
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