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HDAC2 Human shRNA Plasmid Kit (Locus ID 3066)

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SKU
TR312495
HDAC2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 3066
Synonyms HD2; KDAC2; RPD3; YAF1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components HDAC2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3066). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001527, NR_033441, NR_073443, NM_001527.1, NM_001527.2, NM_001527.3, BC013141, BC031055, BC146376, BC148797, BM550464
UniProt ID Q92769
Summary This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. provided by RefSeq, Apr 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases
Huang, Chen, Chou et al
Mol. Pharmacol. (2011) 79 (1), 197-206 DOI: 10.1124/mol.110.067702
Cited by 111
AI Summary: OriGene products contributed to this study by providing shRNA constructs targeting HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, which were used to investigate the roles of specific HDAC isozymes in regulating histone H3K4 methylation and demethylase expression.
Snippet: suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down-regulation of ... shRNA for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 were purchased from Origene, Inc.
Regulation of Nucleocytoplasmic Shuttling of the Transcriptional Regulator Human Mesoderm Induction Early Response 1 α in Breast Carcinoma Cells
Li
Thesis (2018)
Snippet: Plasmids containing ERα shRNA (Cat. No. TR320346), HDAC1 shRNA (Cat. No. TR312496), HDAC2 shRNA (Cat. No. TR312495) or a control scrambled shRNA (Cat. No. TR20003) were purchased from Origene Technologies, Inc
Showing 1-2 of 2 papers.
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