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HDAC6 Human shRNA Plasmid Kit (Locus ID 10013)

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SKU
TR312491
HDAC6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "HDAC6 or NM_001321225"

Specifications
Specifications
Product Data
Locus ID 10013
Synonyms CPBHM; HD6; JM21; PPP1R90
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components HDAC6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 10013). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC011498, NM_001321225, NM_001321226, NM_001321227, NM_001321228, NM_001321229, NM_001321230, NM_001321231, NM_006044, NR_135591, NR_135592, NR_135593, NM_006044.1, NM_006044.2, NM_006044.3, BC011498.1, BC069243, BC005872, BC013219, BC013737, NM_006044.4
UniProt ID Q9UBN7
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα
Zhang, Xiang, Joo et al
Mol. Cell (2014)
Cited by 163
AI Summary: OriGene's HDAC6 shRNA was used to generate HDAC6 knockdown cells, enabling the authors to investigate the role of HDAC6 in regulating MSH2 stability and MutSα levels.
Snippet: mHD6 represents mouse HDAC6. (C) C13 cells were stably transfected with control shRNA(pRS) and HDAC6shRNA (Origene) to generate control (C13-pRS) and HDAC6 knockdown cells (C13-HD6KD), respectively. IP-WB and direct WB were performed as indicated ... Cite SaveSaving
Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases
Huang, Chen, Chou et al
Mol. Pharmacol. (2011) 79 (1), 197-206 DOI: 10.1124/mol.110.067702
Cited by 111
AI Summary: OriGene products contributed to this study by providing shRNA constructs targeting HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, which were used to investigate the roles of specific HDAC isozymes in regulating histone H3K4 methylation and demethylase expression.
Snippet: suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down-regulation of ... shRNA for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 were purchased from Origene, Inc.
Histone deacetylase 6 interacts with the microtubule-associated protein tau
Ding, Dolan, Johnson
J Neurochem (2008) 106 (5), 2119-30 DOI: 10.1111/j.1471-4159.2008.05564.x
Cited by 382
AI Summary: In this study, OriGene products, specifically the HDAC6 shRNA (OriGene) and HDAC6 antibody (OriGene), were used to knock down HDAC6 expression and detect HDAC6 protein levels, respectively, enabling the authors to investigate the interaction and functional relationship between HDAC6 and tau protein.
FigureFigure
Showing 1-3 of 3 papers.
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