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IFNAR1 Human shRNA Plasmid Kit (Locus ID 3454)

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SKU
TR312233
IFNAR1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 3454
Synonyms AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IFNAR1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3454). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000629, NM_000629.1, NM_000629.2, BC021825, BC021825.1, BC002590, BC014338, BC035603, BC065751, NM_000629.3
UniProt ID P17181
Summary The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. provided by RefSeq, Jul 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease
Taylor, Minter, Newman et al
Neurobiol. Aging (2013)
Cited by 151
AI Summary: OriGene’s shRNA plasmid constructs were used to generate IFNAR1 knockdown M17 neuroblastoma cell lines, enabling the study to investigate the role of type-1 interferon signaling in Alzheimer’s disease neuro-inflammation.
Snippet: 2.6. Generation of M17 IFNAR1 knockdown cell line. IFNAR1 (IFNAR1-KD) or negative control (NC) knockdown M17 cells were generated using commercially available shRNA plasmid constructs (Origene, Madison, WI, USA). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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