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IL6 Human shRNA Plasmid Kit (Locus ID 3569)

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SKU
TR312162
IL6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 3569
Synonyms BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IL6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3569). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC015511, NM_000600, NM_001318095, NM_000600.1, NM_000600.2, NM_000600.3, NM_000600.4, NM_000600.5
UniProt ID P05231
Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). provided by RefSeq, Aug 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The IL-6 signaling pathway contributes critically to the immunomodulatory mechanism of human Decidua-derived mesenchymal stromal cells
Na, Im, Kim et al
iScience (2024)
Cited by 13
AI Summary: OriGene’s IL6 Human shRNA Plasmid Kit (Cat#TR312162) was used in this study to specifically knock down IL-6 expression, helping to elucidate the role of IL-6 signaling in the immunomodulatory mechanisms of human decidua-derived mesenchymal stromal cells.
Snippet: IL6 Human shRNA Plasmid Kit Origene Cat#TR312162
Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling
Li, Wang, Brodt
Cancer Res (2012) 72 (4), 865-75 DOI: 10.1158/0008-5472.CAN-11-1357
AI Summary: In this study, OriGene products—specifically, the IL-6 shRNA (OriGene, catalog # TL309598) and gp130 shRNA (OriGene, catalog # TL313085)—were used to knock down IL-6 and gp130 expression, respectively, enabling the authors to demonstrate that blocking autocrine IL-6/STAT3 signaling abolishes the prosurvival and metastatic effects of TNF-α in cancer cells.
Showing 1-2 of 2 papers.
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