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CD61 (ITGB3) Human shRNA Plasmid Kit (Locus ID 3690)

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SKU
TR312082
ITGB3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 3690
Synonyms BDPLT2; BDPLT16; BDPLT24; CD61; GP3A; GPIIIa; GT; GT2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components ITGB3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3690). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000212, NM_000212.1, NM_000212.2, BC127666, BC127667, NM_000212.3
UniProt ID P05106
Summary The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo
Contois, Akalu, Caron et al
Angiogenesis (2014)
Cited by 31
AI Summary: OriGene products contributed to this study by providing the ITGΒ3-shRNA used to generate β3 integrin knockdown (M21β3-KD) melanoma cell variants, enabling investigation of αvβ3 integrin's role in tumor growth and angiogenesis.
Snippet: M21β3-KD cell variant was generated by transfection with β3 integrin specific (ITGΒ3-shRNA) obtained from Origene Technologies (Rockville, MD). M21BP4 overexpressing tumor cell variant was generated by transfection of ... Cite SaveSaving
Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer
Salvo, Garasa, Dotor et al
Mol. Cancer (2014) 13 (1), 112 DOI: 10.1186/1476-4598-13-112
Cited by 43
AI Summary: OriGene’s HuSH™ shRNA Plasmid Panels-29mer targeting integrin β3 were used to stably knock down integrin β3 expression in NSCLC cells, enabling the study of its role in tumor cell adhesion and metastasis in the paper.
Snippet: HuSH TM shRNA Plasmid Panels-29mer targeting integrin β3 (Origene, Rockville, MD, USA) in Opti- MEM medium (Invitrogen, Barcelona, Spain) using a Biorad Gene Pulsar I electroporator (Biorad, Berkeley, USA). Stable ... Cite SaveSaving
Estudio de los mecanismos celulares y moleculares implicados en la adhesión y migración de células de carcinoma pulmonar no microcítico inducidas por TGFß
Salvo
Thesis (2015)
Snippet: Para validar los resultados obtenidos en el array de expresión, se realizaron por triplicado PCRs cuantitativas utilizando cebadores específicos comerciales (Origene, Rockville, MD, EE.UU.) de aquellos genes que al menos duplicaron su expresión tras el tratamiento con TGFβ
Showing 1-3 of 3 papers.
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