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KDM4B Human shRNA Plasmid Kit (Locus ID 23030)

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SKU
TR312052
KDM4B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 23030
Synonyms JMJD2B; TDRD14B
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components KDM4B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 23030). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_015015, NM_015015.1, NM_015015.2, BC015378, BC040014, BC046167, BC063889, BC136611, BC144292, NM_001370093, NM_001370094
UniProt ID O94953
Summary Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 Axis
Liu, Yu, Jin et al
Front Cell Dev Biol (2021) 9, 629893 DOI: 10.3389/fcell.2021.629893
Cited by 41
AI Summary: In this study, OriGene products—including the KDM4B overexpression plasmid (RC204669) and KDM4B siRNA (SR300743)—were used to manipulate KDM4B expression in colorectal cancer cells, enabling the authors to elucidate the role of the KDM4B/HOXC4/PD-L1 axis in immune evasion regulated by miR-15a delivered via mesenchymal stem cell-derived extracellular vesicles.
FigureFigureFigure
Showing 1-1 of 1 papers.
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