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KRIT1 Human shRNA Plasmid Kit (Locus ID 889)

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SKU
TR311844
KRIT1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 889
Synonyms CAM; CCM1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components KRIT1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 889). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001013406, NM_004912, NM_194454, NM_194455, NM_194456, NM_001350669, NM_001350670, NM_001350671, NM_001350672, NM_001350673, NM_001350674, NM_001350675, NM_001350676, NM_001350677, NM_001350678, NM_001350679, NM_001350680, NM_001350681, NM_001350682, NM_001350683, NM_001350684, NM_001350685, NM_001350686, NM_001350687, NM_001350688, NM_001350689, NM_001350690, NM_001350691, NM_001350692, NM_001350693, NM_001350694, NM_001350695, NM_001350696, NM_001350697, NM_194456.1, NM_004912.1, NM_004912.2, NM_004912.3, NM_001013406.1, NM_194455.1, NM_194454.1, BC094684, BC094684.1, NM_194454.2, NM_001013406.2, NM_194454.3, NM_004912.4
UniProt ID O00522
Summary This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Sep 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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