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LETM1 Human shRNA Plasmid Kit (Locus ID 3954)

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SKU
TR311758
LETM1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 3954
Synonyms SLC55A1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components LETM1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3954). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_012318, NM_012318.1, BC021208, BC021208.1, BC014500
UniProt ID O95202
Summary This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. provided by RefSeq, Oct 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux
Austin, Tavakoli, Pfeiffer et al
Front Physiol (2017) 8, 839 DOI: 10.3389/fphys.2017.00839
Cited by 73
AI Summary: OriGene products, specifically LETM1 shRNA (OriGene, Cat# TL313527) and LETM1 cDNA (OriGene, Cat# SC119543), were used in this study to modulate LETM1 gene expression and investigate its role in mitochondrial ion exchange and Ca2+ homeostasis.
FigureFigureFigure
LETM1-mediated K+ and Na+ homeostasis regulates mitochondrial Ca2+ efflux
Austin, Tavakoli, Pfeiffer et al
Frontiers in Physiology (2017)
Cited by 73
AI Summary: OriGene Technologies contributed shRNA constructs for LETM1 (product numbers TR311758A and a second unspecified construct) and control shRNA, which were used to investigate the role of LETM1 in mitochondrial ion homeostasis in the study.
Snippet: Primers are listed in the Table S1. All primers were from Microsynth (Balgach, Switzerland). All shRNA constructs were obtained from Origene Technologies (Rockville, MD). Product numbers for control and constructs by gene are: LETM1 #1 TR311758A) and #2 Cached
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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