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LOXL2 Human shRNA Plasmid Kit (Locus ID 4017)

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SKU
TR311699
LOXL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 4017
Synonyms LOR; LOR2; WS9-14
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components LOXL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4017). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_002318, NM_002318.1, NM_002318.2, BC000594, BC000594.2, BC020481, NM_002318.3
UniProt ID Q9Y4K0
Summary This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane
Bignon, Pichol-Thievend, Hardouin et al
Blood (2011) 118 (14), 3979-89 DOI: 10.1182/blood-2010-10-313296
Cited by 209
AI Summary: OriGene’s human LOXL2 cDNA was used in this study to enable transient overexpression experiments, helping to demonstrate the role of LOXL2 in angiogenesis and collagen IV assembly.
Snippet: Knocking down its expression in zebrafish embryo prevented formation of intersegmental vessels (ISV). ... Human loxl2 cDNA was purchased from Origene and cloned in pcDNA3.1 (Invitrogen) for transient overexpression using a nucleofector device (Amaxa).
Showing 1-1 of 1 papers.
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