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LRRFIP1 Human shRNA Plasmid Kit (Locus ID 9208)

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SKU
TR311663
LRRFIP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 9208
Synonyms FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; TRIP
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components LRRFIP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 9208). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001137550, NM_001137551, NM_001137552, NM_001137553, NM_004735, NM_032674, NM_004735.1, NM_004735.2, NM_004735.3, NM_001137551.1, NM_001137552.1, NM_001137553.1, NM_001137550.1, BC108914, BC108913, BC001385, BC004958, BC010662, BC018883, BC019335, BC071618, BC083492, NM_001137553.2, NM_004735.4, NM_001137550.2
UniProt ID Q32MZ4
Summary Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
Yang, An, Liu et al
Nat Immunol (2010) 11 (6), 487-94 DOI: 10.1038/ni.1876
Cited by 395
AI Summary: In this study, OriGene’s LRRFIP1 expression plasmid (Cat# RC200237) and LRRFIP1 shRNA (Cat# TG310889) were used to manipulate LRRFIP1 levels in macrophages, enabling the authors to demonstrate LRRFIP1’s role in promoting type I interferon production via a beta-catenin-dependent pathway.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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