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Tau (MAPT) Human shRNA Plasmid Kit (Locus ID 4137)

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SKU
TR311569
MAPT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4137
Synonyms DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; tau-40
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MAPT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4137). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001123066, NM_001123067, NM_001203251, NM_001203252, NM_005910, NM_016834, NM_016835, NM_016841, NM_173727, NM_005910.2, NM_005910.3, NM_005910.4, NM_005910.5, NM_016841.1, NM_016841.2, NM_016841.3, NM_016841.4, NM_016835.1, NM_016835.2, NM_016835.3, NM_016835.4, NM_016834.1, NM_016834.2, NM_016834.3, NM_016834.4, NM_001123067.1, NM_001123067.2, NM_001123067.3, NM_001123066.1, NM_001123066.2, NM_001123066.3, NM_001203251.1, NM_001203252.1, NM_173727.1, BC114948, BC000558, BC032572, BC040444, BC061892, BC071830, BC094805, BC098281, BC099721, BC101936, BC114504, NM_016841.5, NM_001203251.2, NM_016834.5
UniProt ID P10636
Summary This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
Bou Samra, Buhagiar-Labarchède, Machon et al
Nat Commun (2017) 8 (1), 693 DOI: 10.1038/s41467-017-00633-1
AI Summary: OriGene’s shRNA plasmid targeting MAPT (TR311569) was used to generate Tau-depleted HeLa cells, enabling the study of Tau’s role in ribosomal DNA stability and cell survival under cytidine deaminase deficiency.
Snippet: HeLa-Ctrl(Tau) and HeLa-shTau cells were obtained by transfecting cells with an empty pRS vector or with the same vector encoding a short hairpin RNA sequence directed against MAPT (Origene, TR311569), respectively, with JetPEI reagent
FigureFigureFigure
Showing 1-1 of 1 papers.
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