MGP Human shRNA Plasmid Kit (Locus ID 4256)

SKU
TR311480
MGP - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*
Specifications
Specifications
Product Data
Locus ID 4256
Synonyms GIG36; MGLAP; NTI
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MGP - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4256). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000900, NM_001190839, NM_000900.1, NM_000900.2, NM_000900.3, NM_000900.4, NM_001190839.1, NM_001190839.2, BC093078, BC005272, BC070314, NM_001190839.3, NM_000900.5
UniProt ID P08493
Summary This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. provided by RefSeq, Sep 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels
Kuzontkoski, Mulligan-Kehoe, Harris et al
Oncogene (2010) 29 (26), 3793-802 DOI: 10.1038/onc.2010.147
Cited by 57
AI Summary: OriGene products, specifically the ID4 (RC209307) and MGP (RC223682) expression plasmids, were used to manipulate gene expression in glioblastoma cell cultures, enabling the authors to investigate the roles of ID4 and MGP in promoting tumor angiogenesis and growth.
Showing 1-1 of 1 papers.
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