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MTA1 Human shRNA Plasmid Kit (Locus ID 9112)

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SKU
TR311372
MTA1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 9112
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MTA1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 9112). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001203258, NM_004689, NM_004689.1, NM_004689.2, NM_004689.3, NM_001203258.1, BC006177, BC009443, BC142941, NM_004689.4
UniProt ID Q13330
Summary This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Feb 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Mechanism of TRIM25 mediated ubiquitination of metastasis associated protein (MTA) 1 in normal liver cells
Li, Zhong, Zang et al
Exp. Cell Res. (2018)
AI Summary: OriGene contributed to this study by providing shRNA targeting the 3'UTR of MTA-1, which was used for gene silencing experiments to investigate the mechanism of TRIM25-mediated ubiquitination of MTA-1 in normal liver cells.
Snippet: ubiquitination sites in proteins, UbPred [15]. 2.3. Gene construction and transfection. Gene silencing for MTA-1 was performed using shRNA targeting the 3'UTR from Origene (Rockville, MD, USA). The coding region of MTA-1
Showing 1-1 of 1 papers.
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