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NUMB Human shRNA Plasmid Kit (Locus ID 8650)

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SKU
TR311064
NUMB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 8650
Synonyms C14orf41; c14_5527; S171
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components NUMB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8650). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001005743, NM_001005744, NM_001005745, NM_001320114, NM_003744, NM_001005745.1, NM_003744.1, NM_003744.2, NM_003744.3, NM_003744.4, NM_003744.5, NM_001005743.1, NM_001005744.1, BC068476, BC068476.1, BC020788, BC033824
UniProt ID P49757
Summary The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

NUMB and NUMBL differences in gene regulation
García-Heredia, Carnero
Oncotarget (2018) 9 (10), 9219-9234 DOI: 10.18632/oncotarget.24186
Snippet: …To downregulate NUMB and NUMBL expression, we used shRNA plasmids from Origene (TR311064, TR311063, Rockville, MD) as previously described [17, 48]. …
FigureFigureFigure
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB
Garcia-Heredia, Lucena-Cacace, Verdugo-Sivianes et al
Clin. Cancer Res. (2017)
AI Summary: OriGene products contributed to this study by providing the pCMV6-XL5-NUMB plasmid (SC301023) for NUMB amplification and the pB-RS sequence control vector (TR311064), which were used in experiments investigating the interaction between MAP17 and NUMB in cancer stem cell regulation.
Snippet: mutagenic PCR in pBabe-puro plasmids. NUMB was amplified from pCMV6-XL5-NUMB (SC301023, Origene) and cloned into pGADT7 vector using EcoRI-BamHI sites. As a result, ... sequence control in pB-RS vectors were obtained from Origene (TR311064, ... All 2 versions Cite SaveSaving
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
García-Heredia, Verdugo Sivianes, Lucena-Cacace et al
Oncotarget (2016) 7 (39), 63611-63628 DOI: 10.18632/oncotarget.11553
Cited by 48
AI Summary: OriGene contributed shRNA constructs targeting NumbL, Numb, and a scrambled sequence control (pB-RS vectors) used to downregulate gene expression and investigate the role of NumbL in tumorigenicity, cancer stem cell properties, and chemoresistance.
Snippet: To downregulate NumbL expression, short hairpins RNA (shRNA) against NumbL, Numb or scrambled sequence control in pB-RS vectors were obtained from Origene (Rockville, MD)
FigureFigureFigure
Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy
Wu, Zhang, Liu et al
J. Physiol. Biochem. (2015)
Cited by 13
AI Summary: OriGene products contributed key genetic constructs to this study, including the C-terminal GFP fusion URAT1 construct, GFP-Numb, Numb-shRNA, GFP-Rab5, GFP-Rab7, and GFP-Rab11, which were used to investigate the cellular mechanisms regulating URAT1 in uric acid nephropathy.
Snippet: URAT1 construct was pur- chased from ORIGENE in a C-terminal GFP fusion form and replaced the GFP by mRFP or Myc by rou- tinely subclone. GFP-Numb, Numb-shRNA, GFP- Rab5, GFP-Rab7, and GFP-Rab11 were all purchased from ORIGENE. ... Cite SaveSaving
Showing 1-4 of 4 papers.
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