NUMBL Human shRNA Plasmid Kit (Locus ID 9253)
SKU
TR311063
NUMBL - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 9253 |
|---|---|
| Synonyms | CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | NUMBL - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 9253). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001289979, NM_001289980, NM_004756, NM_004756.1, NM_004756.2, NM_004756.3, NM_004756.4, NM_001289979.1, NM_001289980.1, NM_001289980.2, BC001794, BC016160, BC144583, BC167835, NM_004756.5, NM_001289979.2 |
| UniProt ID | Q9Y6R0 |
| Summary | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
NUMB and NUMBL differences in gene regulation
García-Heredia, Carnero
Oncotarget (2018) 9 (10), 9219-9234 DOI: 10.18632/oncotarget.24186
García-Heredia, Carnero
Oncotarget (2018) 9 (10), 9219-9234 DOI: 10.18632/oncotarget.24186
Snippet: …To downregulate NUMB and NUMBL expression, we used shRNA plasmids from Origene (TR311064, TR311063, Rockville, MD) as previously described [17, 48]. …
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
García-Heredia, Verdugo Sivianes, Lucena-Cacace et al
Oncotarget (2016) 7 (39), 63611-63628 DOI: 10.18632/oncotarget.11553
García-Heredia, Verdugo Sivianes, Lucena-Cacace et al
Oncotarget (2016) 7 (39), 63611-63628 DOI: 10.18632/oncotarget.11553
Cited by 48
AI Summary: OriGene contributed shRNA constructs targeting NumbL, Numb, and a scrambled sequence control (pB-RS vectors) used to downregulate gene expression and investigate the role of NumbL in tumorigenicity, cancer stem cell properties, and chemoresistance.
Snippet: To downregulate NumbL expression, short hairpins RNA (shRNA) against NumbL, Numb or scrambled sequence control in pB-RS vectors were obtained from Origene (Rockville, MD)
Showing 1-2 of 2 papers.
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