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P4HB Human shRNA Plasmid Kit (Locus ID 5034)

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SKU
TR310639
P4HB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 5034
Synonyms CLCRP1; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components P4HB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5034). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000918, NM_000918.1, NM_000918.2, NM_000918.3, BC029617, BC029617.1, BC010859, BC014504, BC018801, BC071892, NM_000918.4
UniProt ID P07237
Summary This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways
Sun, Lee, Ho et al
Neuro-oncology (2013) 15 (5), 562-77 DOI: 10.1093/neuonc/not005
Cited by 93
AI Summary: OriGene’s pGFP-V-RS plasmid encoding P4HB-specific shRNA was used to knock down P4HB expression in glioma cells, enabling the study to demonstrate that reducing P4HB sensitizes cells to temozolomide and helps overcome drug resistance.
Snippet: In addition, D54-R and U87-R cells were manipulated with P4HB-specific shRNA (shP4HB) encoding pGFP-V-RS plasmid (OriGene Technologies, Inc., Rockville, MD). Green fluorescent protein (GFP) was used to monitor transfection efficiency.
Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure
Popescu, Lupu, Lupu
Blood (2010) 116 (6), 993-1001 DOI: 10.1182/blood-2009-10-249607
Cited by 123
AI Summary: In this paper, OriGene's anti-P4HB (Protein Disulfide Isomerase) antibody (Cat# TA500429) was used to detect extracellular PDI on endothelial cells by imaging and flow cytometry, enabling the study of PDI's role in regulating coagulation through modulation of phosphatidylserine exposure.
Showing 1-2 of 2 papers.
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