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KAT2B Human shRNA Plasmid Kit (Locus ID 8850)

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SKU
TR310589
KAT2B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 8850
Synonyms CAF; P/CAF; PCAF
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components KAT2B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8850). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_003884, NM_003884.2, NM_003884.3, NM_003884.4, BC070075, BC070075.1, BC060823, NM_003884.5
UniProt ID Q92831
Summary CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
Lew, Chu, Lee et al
Nucleic Acids Res. (2011) 39 (2), 429-39 DOI: 10.1093/nar/gkq785
Cited by 28
AI Summary: OriGene's shRNA against PCAF was used in this study to knock down PCAF expression, enabling the authors to demonstrate PCAF's role in mediating XBP-1S-dependent transcription.
Snippet: purchased from Qiagen, and the short hairpin RNAs (shRNA) against PCAF (shPCAF: 5′-TAGATGAGGTGCTTTGAGCAGTTCTGAAA-3′) was obtained from Origene. ... The DNA/protein/antibody complex was then pulled down by protein G agarose and the DNA in the
FigureFigureFigure
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation
Pickard, Wong, McCance
J Cell Sci (2010) 123 (Pt 21), 3718-26 DOI: 10.1242/jcs.068924
Cited by 66
AI Summary: In this study, OriGene’s pCMV6-RB1 (RC204659) and pCMV6-PCAF (RC210880) expression plasmids were used to restore or overexpress RB1 and PCAF proteins, respectively, enabling the authors to investigate the roles of RB1 acetylation and PCAF activity in keratinocyte differentiation and nuclear localization.
Showing 1-2 of 2 papers.
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