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PEX5 Human shRNA Plasmid Kit (Locus ID 5830)

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SKU
TR310491
PEX5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 5830
Synonyms PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1; RCDP5
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PEX5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5830). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000319, NM_001131023, NM_001131024, NM_001131025, NM_001131026, NM_001300789, NM_001351124, NM_001351126, NM_001351127, NM_001351128, NM_001351130, NM_001351131, NM_001351132, NM_001351133, NM_001351134, NM_001351135, NM_001351136, NM_001351137, NM_001351138, NM_001351139, NM_001351140, NM_000319.1, NM_000319.2, NM_000319.3, NM_000319.4, NM_001131024.1, NM_001131025.1, NM_001131026.1, NM_001131023.1, NM_001300789.1, BC010621, BC010621.2, NM_001131024.2, NM_001131025.2, NM_001131026.2, NM_001131023.2, NM_000319.5
UniProt ID P50542
Summary The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Oct 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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